Platelet Rich Plasma (PRP)

Platelet Rich Plasma (PRP) for Alopecia Treatment

Platelet Rich Plasma (PRP) for Alopecia Treatment

What is PRP?

PRP means Platelet Rich Plasma.

PRP is used for therapeutic applications, other than hematological treatment since the end of the 20th century, after the discovery that it contains growth factors. Used to stimulate tissue healing and regeneration. Platelets play crucial role in hemostasis and blood clot formation. They contain granules full of clothing mediators and growth factors (GF). Plasma is the liquid part of the blood which contains cell nutrients, vitamins, hormones, electrolytes and growth factors (IGF, HGF). It also contains proteins (albumins, globulins, clothing factors, and fibrinogen).

How many types of PRP? and What are the differences?

The technology used for PRP preparation affects its composition not only platelet concentration but also the level of contamination with red and white blood cells.

Plasma PRP

Buffy coat PRP

Straw color PRP

Reddish PRP

Low platelet concentration (1-3x)

High platelet concentration (>4x up to 20x)

Virtually no red blood cells

Hematocrit < 1%

Variable red blood cell contamination

Hematocrit 2 to 30%

Low white blood cell concentration (<1X)

Leucocyte poor PRP (LP-PRP)

Highly concentrated while blood cells (>3X)

Leucocyte rich PRP (LR-PRP)

Extremely low level of pro-inflammatory granulocytes

Concentration of pro-inflammatory granulocytes

  There is a study that 1.5X leucocyte poor PRP is as efficient as 4.7x leucocyte rich PRP for intra-articular injections in patients with knee osteoarthritis, with less adverse reactions (Filardo G. et al.2012).

 

PRP Treatments at Kamol Cosmetic Hospital

            We use the Regen Lab: The PRP company system. This is the Swiss pharmaceutical and medical device manufacturing company which is the leader in regenerative medicine. The medical device was certified Class IIb and III according to European medical device directive. The platelet and cell concentrates produced with Regen Lab devices are used with success in many clinical indications (>150 published studies, >80 indexed in PubMed).

 

Alopecia Treatment Pattern

-Point by point injection technique

-Frequency of treatment: every three to four weeks with booster at 6 months

-Minimum number of treatment required = 3

-This protocol increases hair density, and reduces hair loss to normal levels.

 

PRP Treatments combination with Hair Transplant

  • Pre-treatment: 1 to 2 tubes of PRP mesotherapy injections of graft donor and recipient sites to be performed 1-2 weeks prior to grafting.
  • Hair graft day: collect follicular unit grafts and place in PRP for follicular nourishment until re-implantation
  • Directly post grafting, PRP could be applied topically on donor and recipient sites.
  • Post graft treatment: 1 to 2 tubes of PRP mesotherapy injections of graft donor and recipient sites to be performed 3-4 weeks post-grafting.
  • Follow up treatment: Booster at 6 months
  • PRP stimulates and supports hair growth in three main steps:

1. Promoting vascularity to the hair root thereby increasing viability to the follicle before, during and after hair transplantation
2. Promoting tissue repair and regeneration post transplantation
3. Stimulating dormant hair follicles and growing new hair